Enhancing Stem Cell Transplantation with "Nutri-technology"

Valter D Longo; Salvatore Cortellino

doi:10.1016/j.stem.2016.11.015

Enhancing Stem Cell Transplantation with "Nutri-technology"

Cell Stem Cell. 2016 Dec 1;19(6):681-682. doi: 10.1016/j.stem.2016.11.015.

Authors

Valter D Longo¹, Salvatore Cortellino²

Affiliations

¹ Longevity Institute, School of Gerontology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089-0191, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research at USC, Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA; IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, Milan, 20139, Italy. Electronic address: vlongo@usc.edu.
² IFOM FIRC Institute of Molecular Oncology, Via Adamello 16, Milan, 20139, Italy.

Abstract

It is necessary to employ myeloablative irradiation or chemotherapy to deplete the HSC niche to optimize hematopoietic stem cell transplantation. In a recent issue of Science, Taya and colleagues provide evidence for an alternative to the toxic chemoirradiative procedure by showing that a valine-restricted diet is sufficient to empty the bone marrow niche.

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MeSH terms

Bone Marrow
Bone Marrow Transplantation
Hematopoietic Stem Cell Transplantation
Hematopoietic Stem Cells*
Humans
Stem Cell Niche*

Abstract

Publication types

MeSH terms

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